In-Vivo Testing of Anti-Inflammatory Activity of Panyawan Topical Spray

Jenny Bungalan; Franxyne Fei Fuerzas; Cherry Marie Lapiz; Kathleen B. Olaño; Joseph Valen Roales

Authors

Jenny Bungalan University of the Immaculate Conception Author
Franxyne Fei Fuerzas University of the Immaculate Conception Author
Cherry Marie Lapiz University of the Immaculate Conception Author
Kathleen B. Olaño University of the Immaculate Conception Author
Joseph Valen Roales University of the Immaculate Conception Author

Keywords:

Tinospora rumphii, Panyawan Stem Extract, Panyawan Topical Spray, Male Albino Rat, Inflammation, Spray Concentration

Abstract

Background: Inflammation is a common medical concern, and alternative, cost-effective treatments are being explored. Conventional anti-inflammatory drugs, such as NSAIDs, can be expensive and may cause adverse effects. Panyawan (Tinospora rumphii) is a medicinal plant recognized for its anti-inflammatory properties, making it a promising alternative treatment option.
Objective: This study evaluates Panyawan topical spray's efficacy in reducing acute inflammation in a rat paw edema model
Methods: The study evaluated varying concentrations (10%, 5%, and 1% w/v) of Panyawan topical spray against Diclofenac sodium spray and a placebo. A total of 15 male albino rats were randomly assigned to five groups. Paw edema was induced using carrageenan, and paw size was measured at baseline and intervals up to 12 hours post-treatment.
Results: Results indicated that all treatment groups reached baseline paw size, with the 5% Panyawan spray exhibiting the fastest response by the 8th hour, followed by the 1% and 10% Panyawan and Diclofenac sodium sprays at the 10th hour, and the placebo at the 12th hour.
Conclusion: The findings suggest that 5% Panyawan spray has the fastest anti-inflammatory response across three concentrations. However, all treatments are comparable to diclofenac at 10 and 12 hours. Further research is recommended to optimize formulation and enhance therapeutic application.

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